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Disclosure - Supplemental Financial Data link:presentationLink link:definitionLink link:calculationLink 995310 - Disclosure - Revenues link:presentationLink link:definitionLink link:calculationLink 995311 - Disclosure - Collaborative Arrangements and Licensing Agreements link:presentationLink link:definitionLink link:calculationLink 995312 - Disclosure - Basic and Diluted Net Income (Loss) Per Share link:presentationLink link:definitionLink link:calculationLink 995313 - Disclosure - Investments link:presentationLink link:definitionLink link:calculationLink 995314 - Disclosure - Fair Value Measurements link:presentationLink link:definitionLink link:calculationLink 995315 - Disclosure - Stock-based Compensation Expense link:presentationLink link:definitionLink link:calculationLink 995316 - Disclosure - Income Taxes link:presentationLink link:definitionLink link:calculationLink 995317 - Disclosure - Liability Related to Sale of Future Royalties link:presentationLink link:definitionLink link:calculationLink 995318 - Disclosure - Convertible Debt link:presentationLink link:definitionLink link:calculationLink 995319 - Disclosure - Legal Proceedings link:presentationLink link:definitionLink link:calculationLink 995320 - Disclosure - Segment Information link:presentationLink link:definitionLink link:calculationLink 996000 - Disclosure - Accounting Policies, by Policy (Policies) link:presentationLink link:definitionLink link:calculationLink 996001 - Disclosure - Supplemental Financial Data (Tables) link:presentationLink link:definitionLink link:calculationLink 996002 - Disclosure - Revenues (Tables) link:presentationLink link:definitionLink link:calculationLink 996003 - Disclosure - Collaborative Arrangements and Licensing Agreements (Tables) link:presentationLink link:definitionLink link:calculationLink 996004 - Disclosure - Basic and Diluted Net Income (Loss) Per Share (Tables) link:presentationLink link:definitionLink link:calculationLink 996005 - Disclosure - Investments (Tables) link:presentationLink link:definitionLink link:calculationLink 996006 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:definitionLink link:calculationLink 996007 - Disclosure - Stock-based Compensation Expense (Tables) link:presentationLink link:definitionLink link:calculationLink 996008 - Disclosure - Liability Related to Sale of Future Royalties (Tables) link:presentationLink link:definitionLink link:calculationLink 996009 - Disclosure - Convertible Debt (Tables) link:presentationLink link:definitionLink link:calculationLink 996010 - Disclosure - Segment Information (Tables) link:presentationLink link:definitionLink link:calculationLink 996011 - Disclosure - Organization and Basis of Presentation (Details) link:presentationLink link:definitionLink link:calculationLink 996012 - Disclosure - Supplemental Financial Data - Inventories (Details) link:presentationLink link:definitionLink link:calculationLink 996013 - Disclosure - Supplemental Financial Data - Accrued Liabilities (Details) link:presentationLink link:definitionLink link:calculationLink 996014 - Disclosure - Revenues (Details) link:presentationLink link:definitionLink link:calculationLink 996015 - Disclosure - Revenues - Revenues (Details) link:presentationLink link:definitionLink link:calculationLink 996016 - Disclosure - Collaborative Arrangements and Licensing Agreements - AstraZeneca (Details) link:presentationLink link:definitionLink link:calculationLink 996017 - Disclosure - Collaborative Arrangements and Licensing Agreements - Revenue from Collaborative Relationship from AstraZeneca (Details) link:presentationLink link:definitionLink link:calculationLink 996018 - Disclosure - Collaborative Arrangements and Licensing Agreements - Ono (Details) link:presentationLink link:definitionLink link:calculationLink 996019 - Disclosure - Collaborative Arrangements and Licensing Agreements - Revenue from Collaborative Relationship from Ono (Details) link:presentationLink link:definitionLink link:calculationLink 996020 - Disclosure - Basic and Diluted Net Income (Loss) Per Share (Details) link:presentationLink link:definitionLink link:calculationLink 996021 - Disclosure - Basic and Diluted Net Income (Loss) Per Share - Diluted Net Income (Loss) Per Share (Details) link:presentationLink link:definitionLink link:calculationLink 996022 - Disclosure - Investments (Details) link:presentationLink link:definitionLink link:calculationLink 996023 - Disclosure - Investments - Contract Maturity of Available-for-Sale Securities (Details) link:presentationLink link:definitionLink link:calculationLink 996024 - Disclosure - Investments - Summary of Investments (Details) link:presentationLink link:definitionLink link:calculationLink 996025 - Disclosure - Investments - Temporarily Impaired Investments (Details) link:presentationLink link:definitionLink link:calculationLink 996026 - Disclosure - Fair Value Measurements (Details) link:presentationLink link:definitionLink link:calculationLink 996027 - Disclosure - Fair Value Measurements - Fair Value Measurements (Details) link:presentationLink link:definitionLink link:calculationLink 996028 - Disclosure - Stock-based Compensation Expense (Details) link:presentationLink link:definitionLink link:calculationLink 996029 - Disclosure - Stock-based Compensation Expense - Stock-based Compensation Expense (Details) link:presentationLink link:definitionLink link:calculationLink 996030 - Disclosure - Stock-based Compensation Expense - Weighted-Average Assumptions for Stock Options (Details) link:presentationLink link:definitionLink link:calculationLink 996031 - Disclosure - Stock-based Compensation Expense - Weighted-Average Assumptions for ESPP (Details) link:presentationLink link:definitionLink link:calculationLink 996032 - Disclosure - Liability Related to Sale of Future Royalties (Details) link:presentationLink link:definitionLink link:calculationLink 996033 - Disclosure - Liability Related to Sale of Future Royalties - Liability Related to Sale of Future Royalties (Details) link:presentationLink link:definitionLink link:calculationLink 996034 - Disclosure - Convertible Debt (Details) link:presentationLink link:definitionLink link:calculationLink 996035 - Disclosure - Convertible Debt - 1.75% Notes (Details) link:presentationLink link:definitionLink link:calculationLink 996036 - Disclosure - Convertible Debt - 0% Notes (Details) link:presentationLink link:definitionLink link:calculationLink 996037 - Disclosure - Segment Information (Details) link:presentationLink link:definitionLink link:calculationLink 996038 - Disclosure - Segment Information - Segment Information (Details) link:presentationLink link:definitionLink link:calculationLink 000 - Document - Document And Entity Information link:presentationLink link:definitionLink link:calculationLink 996039 - Disclosure - AdditionalCalculations link:presentationLink link:definitionLink link:calculationLink