000100 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 010000 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 010100 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 020000 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 030000 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 040000 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 050000 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 050100 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 060100 - Disclosure - Organization and Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 060200 - Disclosure - Supplemental Financial Data link:presentationLink link:calculationLink link:definitionLink 060300 - Disclosure - Revenues link:presentationLink link:calculationLink link:definitionLink 060400 - Disclosure - Collaborative Arrangements and Licensing Agreements link:presentationLink link:calculationLink link:definitionLink 060500 - Disclosure - Investments link:presentationLink link:calculationLink link:definitionLink 060600 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 060700 - Disclosure - Long-Term Obligations and Commitments link:presentationLink link:calculationLink link:definitionLink 060800 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 060900 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 061000 - Disclosure - Employment Benefits link:presentationLink link:calculationLink link:definitionLink 061100 - Disclosure - Legal Proceedings link:presentationLink link:calculationLink link:definitionLink 061200 - Disclosure - Fourth Quarter Financial Data (Unaudited) link:presentationLink link:calculationLink link:definitionLink 061300 - Disclosure - Insider Trading Arrangements link:presentationLink link:calculationLink link:definitionLink 070100 - Disclosure - Organization and Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 080100 - Disclosure - Organization and Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 080200 - Disclosure - Supplemental Financial Data (Tables) link:presentationLink link:calculationLink link:definitionLink 080300 - Disclosure - Revenues (Tables) link:presentationLink link:calculationLink link:definitionLink 080400 - Disclosure - Collaborative Arrangements and Licensing Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 080500 - 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Disclosure - Organization and Significant Accounting Policies, Research, Development and Patent Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 090108 - Disclosure - Organization and Significant Accounting Policies, Basic and Diluted Net Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 090114 - Disclosure - Organization and Significant Accounting Policies, Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 090118 - Disclosure - Organization and Significant Accounting Policies, Cash, Cash Equivalents and Investments (Details) link:presentationLink link:calculationLink link:definitionLink 090122 - Disclosure - Organization and Significant Accounting Policies, Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 090130 - Disclosure - Organization and Significant Accounting Policies, Convertible Debt (Details) link:presentationLink link:calculationLink link:definitionLink 090132 - Disclosure - Organization and Significant Accounting Policies, Call Spread (Details) link:presentationLink link:calculationLink link:definitionLink 090134 - Disclosure - Organization and Significant Accounting Policies, Segment Information (Details) link:presentationLink link:calculationLink link:definitionLink 090200 - Disclosure - Supplemental Financial Data, Inventories (Details) link:presentationLink link:calculationLink link:definitionLink 090202 - Disclosure - Supplemental Financial Data, Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 090204 - Disclosure - Supplemental Financial Data, Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 090300 - Disclosure - Revenues (Details) link:presentationLink link:calculationLink link:definitionLink 090402 - Disclosure - Collaborative Arrangements and Licensing Agreements, Biogen (Details) link:presentationLink link:calculationLink link:definitionLink 090404 - Disclosure - Collaborative Arrangements and Licensing Agreements, AstraZeneca (Details) link:presentationLink link:calculationLink link:definitionLink 090408 - Disclosure - Collaborative Arrangements and Licensing Agreements, GSK (Details) link:presentationLink link:calculationLink link:definitionLink 090410 - Disclosure - Collaborative Arrangements and Licensing Agreements, Novartis (Details) link:presentationLink link:calculationLink link:definitionLink 090414 - Disclosure - Collaborative Arrangements and Licensing Agreements, Roche (Details) link:presentationLink link:calculationLink link:definitionLink 090416 - Disclosure - Collaborative Arrangements and Licensing Agreements, Otsuka (Details) link:presentationLink link:calculationLink link:definitionLink 090418 - Disclosure - Collaborative Arrangements and Licensing Agreements, PTC Therapeutics (Details) link:presentationLink link:calculationLink link:definitionLink 090420 - Disclosure - Collaborative Arrangements and Licensing Agreements, Sobi (Details) link:presentationLink link:calculationLink link:definitionLink 090424 - Disclosure - Collaborative Arrangements and Licensing Agreements, Bicycle Therapeutics (Details) link:presentationLink link:calculationLink link:definitionLink 090426 - Disclosure - Collaborative Arrangements and Licensing Agreements, Metagenomi (Details) link:presentationLink link:calculationLink link:definitionLink 090430 - Disclosure - Collaborative Arrangements and Licensing Agreements, Alnylam Pharmaceuticals, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 090500 - Disclosure - Investments, Contract Maturity of Available-for-Sale Securities (Details) link:presentationLink link:calculationLink link:definitionLink 090502 - Disclosure - Investments, Summary of Investments (Details) link:presentationLink link:calculationLink link:definitionLink 090504 - Disclosure - Investments, Investments Temporarily Impaired (Details) link:presentationLink link:calculationLink link:definitionLink 090504 - Disclosure - Investments, Summary of Investments (Details) Calc 2 link:presentationLink link:calculationLink link:definitionLink 090600 - Disclosure - Fair Value Measurements (Details) link:presentationLink link:calculationLink link:definitionLink 090700 - Disclosure - Long-Term Obligations and Commitments, Long-Term Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 090702 - Disclosure - Long-Term Obligations and Commitments, Convertible Debt and Call Spread (Details) link:presentationLink link:calculationLink link:definitionLink 090704 - Disclosure - Long-Term Obligations and Commitments, Financing Arrangements (Details) link:presentationLink link:calculationLink link:definitionLink 090706 - Disclosure - Long-Term Obligations and Commitments, Debt Maturity Schedules (Details) link:presentationLink link:calculationLink link:definitionLink 090708 - Disclosure - Long-Term Obligations and Commitments, Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 090710 - Disclosure - Long-Term Obligations and Commitments, Future Payments for Operating Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 090712 - Disclosure - Long-Term Obligations and Commitments, Royalty Revenue Monetization (Details) link:presentationLink link:calculationLink link:definitionLink 090800 - Disclosure - Stockholders' Equity, Preferred and Common Stock (Details) link:presentationLink link:calculationLink link:definitionLink 090804 - Disclosure - Stockholders' Equity, Stock Plans (Details) link:presentationLink link:calculationLink link:definitionLink 090806 - Disclosure - Stockholders' Equity, Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 090808 - Disclosure - Stockholders' Equity, Restricted Stock Unit Activity (Details) link:presentationLink link:calculationLink link:definitionLink 090810 - Disclosure - Stockholders' Equity, Performance Restricted Stock Unit Activity (Details) link:presentationLink link:calculationLink link:definitionLink 090812 - Disclosure - Stockholders' Equity, Stock-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 090814 - Disclosure - Stockholders' Equity, Stock-based Valuation Information (Details) link:presentationLink link:calculationLink link:definitionLink 090900 - Disclosure - Income Taxes, Loss Before Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 090902 - Disclosure - Income Taxes, Income Tax Expense (Benefit) (Details) link:presentationLink link:calculationLink link:definitionLink 090904 - Disclosure - Income Taxes, Reconciliation of Statutory to Effective Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 090906 - Disclosure - Income Taxes, Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 090908 - Disclosure - Income Taxes, Tax Credit Carryforwards (Details) link:presentationLink link:calculationLink link:definitionLink 090910 - Disclosure - Income Taxes, Gross Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 091000 - Disclosure - Employment Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 091200 - Disclosure - Fourth Quarter Financial Data (Unaudited) (Details) link:presentationLink link:calculationLink link:definitionLink